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Collagen Peptides Clinical Studies

Hydrolyzed Collagen Clinically Studied with Proven Results.

60+ clinical published studies on hydrolyzed collagen (footnote 1)

>90% Absorption rate

>78% Increase in dermis density (footnote3)

>30% Decrease in deep wrinkles formation. (footnote4)

Collagen Peptides Clinical Studies on Skin

1. An Overview of the Beneficial Effects of Hydrolysed Collagen supplements as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies Sibilla S, Godfrey M et al, , London UK.3Dr. Anil Anti-Ageing and Parkfield Medical Centre, Birmingham, UK. The Open Nutraceuticals Journal, 2015, 8, 29-42.

http://benthamopen.com/contents/pdf/TONUTRAJ/TONUTRAJ-8-29.pdf

2.The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: J Cosmet Dermatol. 2015 Dec;14(4):291-301. doi: 10.1111/jocd.12174. Epub 2015 Sep 12. http://www.ncbi.nlm.nih.gov/pubmed/26362110

3. Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study Proksch E et al., Dept. of Dermatology, University of Kiel, Kiel, Germany. Skin Pharmacol Phy., Aug. 2013; 27(1):47-55.
http://www.ncbi.nlm.nih.gov/pubmed/23949208

4. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts Ohara H et al., Food and Health R&D Laboratories, Meiji Seika Kaisha, Saitama, Japan. Journal of Dermatology, 2010 Apr; 37(4):330-8.
http://www.ncbi.nlm.nih.gov/pubmed/20507402

5. Effects of Sizes and Conformations of Fish-Scale Collagen Peptides on Facial Skin Qualities and Transdermal Penetration Efficiency Huey-Jine Chai et al., Dept. of Food Science, National Taiwan Ocean University, Keelung, Taiwan. Journal of Biomedicine and Biotechnology, Vol. 2010.
https://www.hindawi.com/journals/bmri/2010/757301/

6. Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity JOURNAL OF MEDICINAL FOOD J Med Food 14 (6) 2011, 618–624
http://www.sbne.org.br/pdf/AC-Collagen-Hydrolysate-Intake-Increases-Skin-Collagen-Expression-and-Suppresses-Matrix-Metalloproteinase-2-Activity.pdf

7. Clinical Effects of Fish Type I collagen hydrolysate on skin properties
Hitoshi Matsumoto, et al., ITE Letters on batteries, new technologies and medicine, 2006.
http://www.academia.edu/8661820/Hydrolyzed_Collagen_and_Skin_Health_2009_clinical_studies_results

8. Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in Achilles tendon
Minaguchi Jun (Rakuno Gakuen University, Hokkaido, Japan) et al., 2005.
http://www.bioin.gr/uploads/links/files/fdfe7fda4730c3004d44213707d879b2_108.pdf

9. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates
Iwai K et al, Kyoto Prefectural University, Japan. Journal of Agricultural Food Chemistry, 2005 Aug 10; 53(16):6531-6.

10. Effect of the Collagen Peptide Drinks on the Elastic Properties of Facial Skin in Normal Volunteers Hayamizu Kosuke et al. Journal of New Remedies & Clinics, Japan, 2000; 49-9:867-873.

11. Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis a Department of Dermatology, University of Kiel, and b Collagen Research Institute, Kiel , and c Skin Investigation and
Technology, Hamburg , Germany;
https://www.karger.com/Article/Pdf/355523

Footnotes

(1) An Overview of the Beneficial Effects of Hydrolyzed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies; The Open Nutraceutical Journal, 2015; 8: 29-42.
(2) Oral Administration of (14)C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice; Journal of Nutrition, 1999; 129(10): 1891-5.
(3) A Novel Micronutrient Supplement in Skin Aging: A Randomized Placebo-controlled Double-blind Study; Journal of Cosmetic Dermatology, 2005; 4
(4): 277-84. (4) Hydrolyzed Collagen & Skin Health Study YNTKK – 2008; Rousselot, France Anti-aging; 2009 corporate publication.

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